主讲课程 : 分子生物学、基因工程实验技术I
教育背景:
中国农业大学,生物化学与分子生物学博士;
河北农业大学,动物生产学硕士;
河北农业大学,畜牧学学士。
主持课题:
河北省现代农业产业技术体系肉牛团队岗位专家(HBCT2023190202),2023-2027
河北自然科学基金:DLKI-DIO3 印记区MEG8-DMR 调控克隆奶牛胚胎发育的分子机理研究(C2023204145),2023-2025
河北自然科学基金:IG-DMR 编码的增强子 RNA 调控克隆胚胎供体核重编程的机理(C2020204004),2020-2022
河北省自然科学基金:牛Gab1和Sfmbt2基因组印记及在体细胞克隆牛中重编程研究(C2016204092),2016-2018
国家自然科学基金:体细胞克隆牛Dlk1/Dio3印记区域ncRNA和miRNA重编程研究(31372312),2014-2017
国家自然科学基金:细胞克隆牛Dlk1-Gtl2印记区域表观遗传重编程的研究(30972098), 2010-2012
代表性学术成果
获奖情况:
河北省自然科学二等奖:体细胞核移植牛中基因表达与DNA 甲基化研究(2009),排名第1,,
近期论文:
1、Huo H, Zhang C, Wang K, Wang S, Chen W, Zhang Y, Yu W, Li S, Li S*, A novel imprinted locus on bovine chromosome 18 homologous with human Chromosome 16q24.1, Mol Genet Genomics. 2024 Mar 28;299(1):40.
2、Zhang Y, Zhang C, Chen W, Huo H, Li S, Yu W, Jin L, Wang K, Li S*., The landscape of the genomic imprinting and DNA methylatin at the bovine SGCE/PEG10 locus, Anim Genet. 2024 Jun;55(3):452-456.
3、 Li J, Yu D, Wang J, Li C, Wang Q, Wang J, Du W, Zhao S, Pang Y, Hao H, Zhao X, Zhu H, Li S*, Zou H. Identification of the porcine IG-DMR and abnormal imprinting of DLK1- DIO3 in cloned pigs. Front Cell Dev Biol. 2022;10:964045.
4、 Liu X, Huo H, Jin L, Dong Y, Li D, Zhang C, Li S*. Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice. Theriogenology. 2022;180:121-129
5、 Chen W, Ma C, Dong Y, Li S*. The bovine Prader-Willi/Angelman imprinted domain has four Sno-lncRNAs types. Anim Genet. 2022;53(5):685-689
6、 Dong Y, Jin L, Liu X, Li D, Chen W, Huo H, Zhang C, Li S*. IMPACT and OSBPL1A are two isoform-specific imprinted genes in bovines. Theriogenology. 2022;184:100-109
7、 Dong Y, Zhang C, Jin L, Li D, Chen W, Huo H, Li S*. PMM2 and NARFL are paternally imprinted genes in bovines. Anim Genet. 2022;53(5):592-598
8、Li J, Chen W, Li D, Gu S, Liu X, Dong Y, Jin L, Zhang C, Li S*. Conservation of Imprinting and Methylation of MKRN3, MAGEL2 and NDN Genes in Cattle. Animals (Basel). 2021; 11(7):1985.
9、 Li J, Zhang C, Si H, Gu S, Liu X, Li D, Meng S, Yang X, Li S*. Brain-specific monoallelic expression of bovine UBE3A is associated with genomic position. Anim Genet. 2021; 52(1):47-54.
10、Gu S, Li J, Chen W, Li D, Zhang C, Li R, Xu D, Zhang C, Li S*. ZNF597 is a maternally expressed imprinted gene in the Holstein breed. Theriogenology. 2020; 143:133-138.
11、Chen W, Xu D, Ma , Zhang C, Li J, Zhang W, Zhao G, Li S*. The molecular structure and imprinting status of IPW (Imprinted gene in the Prader-Willi syndrome region) gene in cattle.Animal genetic. 2019; 50(5):417-422.
12、Zhang C , Xu D, Chen W, Li J, Gao Q, Li S*. LINC24065 is a monoallelically expressed long intergenic noncoding RNA located in the cattle DLK1-DIO3 cluster. J Genet. 2019; 98(1):30.